Differential Effects of the /J-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1- and SQT2-Mutant Channels

ILONA BODI; GERLIND FRANKE; NAGA DEEPA PANTULU; Ph.D.; KEZHONG WU; STEFANIE PEREZ-FELIZ; CHRISTOPH BODE; M.D.

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Differential Effects of the /J-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1- and SQT2-Mutant Channels

机译：/ J-肾上腺素受体阻滞剂卡维地洛和美托洛尔对SQT1和SQT2突变通道的差异作用

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beta-Blocker Effects on SQTS-Mutant K~+ Channels. Background: N588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I_(Kr) and I_(Ks) thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and beta-blockers are effective in SQTS. Since (5-blockers can block I_(Kr) and I_(ks), we aimed at determining carvedilol's and metoprolol's electrophysiological effects on N588K-KCNH2 and V307L-KCNQ1 channels.

机译：β-阻滞剂对SQTS突变K〜+通道的影响。背景：N588K-KCNH2和V307L-KCNQ1突变导致I_（Kr）和I_（Ks）的功能获得，从而导致短QT综合征（SQT1，SQT2）。使用K +通道阻滞剂和β阻滞剂的联合药物治疗在SQTS中有效。由于（5-阻滞剂可以阻断I_（Kr）和I_（ks），因此我们旨在确定卡维地洛和美托洛尔对N588K-KCNH2和V307L-KCNQ1通道的电生理作用。

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《Journal of cardiovascular electrophysiology》 |2013年第10期|共9页
作者
ILONA BODI; GERLIND FRANKE; NAGA DEEPA PANTULU; Ph.D.; KEZHONG WU; STEFANIE PEREZ-FELIZ; CHRISTOPH BODE; M.D.;
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1. Differential Effects of the /J-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1- and SQT2-Mutant Channels [J] . ILONA BODI, GERLIND FRANKE, NAGA DEEPA PANTULU, Journal of cardiovascular electrophysiology . 2013,第10期

机译：/ J-肾上腺素受体阻滞剂卡维地洛和美托洛尔对SQT1和SQT2突变通道的差异作用
2. Differential effects of carvedilol and metoprolol on renal function in patients with heart failure. [J] . Ito H, Nagatomo Y, Kohno T, Circulation journal . 2010,第8期

机译：卡维地洛和美托洛尔对心力衰竭患者肾功能的差异作用。
3. Differential Effects of Carvedilol and Metoprolol on Renal Function in Patients With Heart Failure [J] . Hiroyuki Ito, Yuji Nagatomo, Takashi Kohno, Circulation journal . 2010,第8期

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4. Effects of the β-Adrenoceptor Blocker Carvedilol in Short QT Syndrome Caused by N588K Mutation in HERG: A Simulation Study [C] . Cunjin Luo, Linghua Li, Tong Liu, Computing in Cardiology Conference . 2018

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5. A study on effects of fosphenytoin, a sodium channel blocker, on the post-ischemic rat hippocampus. [D] . Chan, Shyue-An. 1999

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Differential Effects of the /J-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1- and SQT2-Mutant Channels

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