Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism and migraine

摘要

Recently Alsayouf et al reported their experience about the homozygosity for the methylenetetrahydrofolate reductase (MTHFR) 677OT mutation in the Journal of Child Neurology} They performed a retrospective review of 533 children tested for the MTHFR 677OT mutation, and observed homozygosity in 57 (10.6%). There was no difference in the prevalence between the patients with cerebrovascular disorders and the general population. Eleven migraine patients (26.8%) with and without aura were homozygous for the MTHFR 677OT mutation, and 15 migraine patients (36.6%) were heterozygous. The authors suggest that the MTHFR TT genotype could influence migraine susceptibility in children.In this sense, we have an investigation in progress in which we tested 214 children and adolescents for the MTHFR 677OT mutation, and observed homozygosity in 28 (13.08%). Two of 7 migraine patients without aura (28.57%) were homozygous for the MTHFR 677OT mutation, and 2 other migraine patients without aura (28.57%) were heterozygous.