Retrospective study of neuroblastoma in Chinese neonates from 1994 to 2011: An evaluation of diagnosis, treatments, and prognosis: A 10-year restrospective study of neonatal neuroblastoma

摘要

Purpose: The purpose of the study is to review the clinical features, treatments, and outcomes of neonatal neuroblastoma (NB). Methods: A retrospective analysis was performed on 42 patients with NB between January 1994 and December 2011. Results: MYCN amplification was detected in nine tumor samples. The ratio of unfavorable histology to favorable histology was 1:2 in NB patients. The 5-year overall survival (OS) of NB patients was 85.7 %. The 5-year OS in patients in the operation group was 83.3 %, chemotherapy group was 83.3 %, and the "wait-and-see" group was 100 % (P = 0.04). Overall, the prognosis was favorable, except in patients with elevated MYCN amplification or vanillylmandelic acid. Conclusions: NB patients were more sensitive and vulnerable to chemotherapy and operation. The "wait-and-see" strategy should be highlighted in the treatment of NB.