Left ventricular apical aneurysm and systolic dysfunction in hypertrophic cardiomyopathy

摘要

Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder that causes distinctive anatomic and histologic features as well as a wide array of clinical manifestations [1 ]. HCM is the most frequent cause of sudden cardiac death in young athletes [2]. Morphologic features of HCM include ventricular hypertrophy that is usually asymmetric and particularly involves the interven-tricular septum. Epidemiologic data indicate that 2 in 1000 young adults have unexplained hypertrophy [2]. Mutations in genes that encode sarcomere proteins including cardiac myosin binding protein C gene {MYBPC3), cardiac troponin T gene {TNNT2), cardiac troponin I gene (TNNB), and cardiac beta-myosin heavy chain gene {MYH7) are well-established causes of the disease [1,3]- Studies in populations with familial HCM often reported that mutations in sarcomere