A prospective comparison of sequential chemoradiation vs concurrent chemoradiation in locally advanced oropharyngeal carcinomas

摘要

Purpose: Induction chemotherapy has shown to provide consistent benefit for local control in primary treatment of advanced oropharyngeal cancer. The beneficial role of chemoradiation following induction chemotherapy over concurrent chemoradiation has not been evaluated. Present study evaluates the same prospectively.Results: The response rate and acute toxicity (primary end points) in both die arms were found to be similar (p > 0.05) The points disease free survival and overall survival (secondary end points) were significantly (p < 0.05) better in treatment arm as compared to control arm.