Pneumonia in Elderly Australians: Reduction in Presumptive Pneumococcal Hospitalizations but No Change in All-Cause Pneumonia Hospitalizations Following 7-Valent Pneumococcal Conjugate Vaccination

摘要

We analyzed all hospitalizations coded as pneumonia from 1998 to 2011. Following the start of infant conjugate pneumococcal vaccination in 2005, presumptive pneumococcal codes decreased in all age groups, but all-cause pneumonia decreased only in children aged < 5 years.Methods.aEuro integral We estimated vaccine impact on hospitalizations coded as pneumonia (pneumococcal/lobar, other specified, unspecified, and all-cause) using a multivariate negative binomial regression model of monthly hospitalization rates by age group for the pre-PCV7 (July 1998 to December 2004) and post-PCV7 (January 2005 to June 2011) periods, adjusting for vaccination coverage. Changes in pneumonia hospitalizations were measured as incidence rate ratios.