Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors

Li Albert P.; Doshi Utkarsh

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Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors

机译：慢速代谢化合物的反应表型使用平板肝细胞中继法结合基于机制的同工型特异性P450抑制剂

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《Drug Metabolism Reviews 》 |2016年第4期| 共2页
作者
Li Albert P.; Doshi Utkarsh;
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正文语种 eng
中图分类药理学 ;
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1. Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors [J] . Li Albert P., Doshi Utkarsh Drug Metabolism Reviews . 2016 ,第1a4期

机译：慢速代谢化合物的反应表型使用平板肝细胞中继法结合基于机制的同工型特异性P450抑制剂
2. Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors [J] . Li Albert P., Doshi Utkarsh Drug Metabolism Reviews . 2016 ,第1a4期

机译：慢速代谢化合物的反应表型使用平板肝细胞中继法结合基于机制的同工型特异性P450抑制剂
3. Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors [J] . Li Albert P., Doshi Utkarsh Drug Metabolism Reviews . 2016 ,第1a4期

机译：使用电镀肝细胞继电器方法与机理为基础的同种型P450抑制剂的反应表型使用电镀肝细胞继电器方法
4. COMPARATIVE STUDIES ON INTRINSIC CLEARANCE PREDICATION OF LOW TURNOVER COMPOUNDS USING THE REGULAR AND RELAY CRYOPRESERVED HEPATOCYTE METHODS [C] . MIN JIANG, DAN ROCK, ZHICAN WANG ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用规则和继电器冷冻保存的肝细胞方法对低端复合化合物的内在清除预测的比较研究
5. An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors including isoniazid [O] . Thomas M Polasek, David J Elliot, Andrew A Somogyi, 2006

机译：通过单胺氧化酶抑制剂（包括异烟肼）对人体药物代谢细胞色素P450潜在的基于机制的失活进行评估
6. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac [O] . Tom S. Chan, Hongbin Yu, Amanda Moore, 2018

机译：使用新型肝细胞模型，通过细胞色素模型缓慢地代谢化合物的肝脏清除症的挑战，肝脏模型缓慢地由细胞色素P450慢慢地代谢

Reaction phenotyping of slowly metabolized compounds using the plated hepatocyte relay method in combination with mechanism-based isoform-specific P450 inhibitors

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