BACKGROUND: Asthma affects millions of children in the United States. The extent to which asthma and other medical conditions coexist, however, is largely unknown. OBJECTIVE: This study aimed to determine associations between symptomatic asthma and neurobehavioral comorbidities among children in rural United States. METHODS: This cross-sectional study used data from 406 parents/caregivers of children aged 16 or younger, who completed survey questionnaires assessing their child's health status. Symptomatic asthma was defined as parents'/caregivers' report of physician diagnosed asthma and presence of night-time asthma symptoms in their children. The dependent variables were parents'/caregivers' reported comorbidities in children. RESULTS: Symptomatic asthma was present in 9% of the sample. Approximately 26% parents/caregivers reported their child had one or more mental health problems and 13% reported one or more neurological problems. In multivariable logistic regression analyses, a statistically nonsignificant 50% elevated odds of one or more mental health problems were observed for children with symptomatic asthma (adjusted odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.6-3.5). Of the individual comorbidities included in the mental health construct, more than 2-fold elevated odds of anxiety problems (adjusted OR = 2.6, 95% CI = 0.8-8.6) and attentional problems (adjusted OR = 2.4, 95% CI = 1.0-5.8) were observed for symptomatic asthma. The odds of reporting one or more neurological problems were 4-fold elevated (adjusted OR = 4.0, 95% CI = 1.6-10.0) for symptomatic asthma. Of the individual comorbidities included in the neurological construct a significantly elevated odds of hearing impairment or deafness was observed among children with symptomatic asthma (adjusted OR = 8.2, 95% CI = 1.5-45.3) as compared to the no asthmao symptoms reference group. CONCLUSION: These data suggest significant associations between symptomatic asthma and neurological comorbidities.
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