Drug Release from Poly(ortho esters)-Poly(ethylene glycol) Polyblend

摘要

A polyblend of polyblend of poly(ortho esters)-poly(ethylene glycol) (POE-PEG) was prepared.The release behavior of the acetanilide-loaded film of the POE-PEG poly-blend was studied.Blending POE with water-soluble PEG can promote the release of drug in pH 7.4 PBS buffer at 37degC,while POE has plasticizing effect on PEG.Infrared and X-ray diffraction studies reveal that there is some interaction between POE and actanilide.The SEM micrographs disclose that the porosity of the drug-loaded film enhances with an increase immersing time.