First multiparametric cardiovascular magnetic resonance study using ultrasmall superparamagnetic iron oxide nanoparticles in a patient with acute myocardial infarction: New vistas for the clinical application of ultrasmall superparamagnetic iron oxide

摘要

After coronary angiography, the patient was enrolled in an ongoing clinical trial (Non-invasive myocardial inflammation imaging study 2 [NIMINI-2]) that is attempting to evaluate whether myocardial infarct imaging using ultrasmall superpara-magnetic iron oxide nanoparticles (USPIO) and multiparametric cardiovascular magnetic resonance (CMR) techniques allow an improved characterization of infarct as well as peri-infarct pathology (compared with conventional gadolinium-based ne-crosis/fibrosis imaging). Therefore, multiparametric CMR studies were performed before and after intravenous ferumoxytol (Feraheme, a USPIO; 17 mL IV=510 mg Fe) administration. The first CMR (pre-Feraheme) was performed 3 days after presentation with acute ST-elevation myocardial infarction. Serial CMR studies were then performed 6 hours, 24 hours, 48 hours, 96 hours, and 3 months after intravenous Feraheme administration (post-Feraheme). Only the first (pre-Feraheme) and last CMR study (3 months post-Feraheme) comprised additional late-gadolinium enhancement (LGE) images 10 minutes after intravenous administration of a gadolinium-based contrast agent (0.15 mmol/kg Magnevist).