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首页> 外文期刊>Journal of Analytical Toxicology >The prevalence of marijuana in suspected impaired driving cases in Washington state.
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The prevalence of marijuana in suspected impaired driving cases in Washington state.

机译:华盛顿州怀疑驾驶案例中的大麻流行。

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摘要

In December 2012, the possession and private use of limited quantities of marijuana and marijuana products became legal in the state of Washington. At the same time, the state's driving under the influence statutes were amended to include a per se level of 5 ng/mL delta(9)-tetrahydrocannabinol (THC) in whole blood for drivers aged 21 years and older. The aim of this study was to assess the effect of marijuana legalization on the prevalence of marijuana in suspected impaired driving cases. The prevalence of both active THC and its metabolite carboxy-THC detected in such cases pre-legalization was compared with the prevalence post-legalization. In 2009-2012, the average yearly percentage of cases positive for THC and carboxy-THC was 19.1% (range: 18.2-20.2%) and 27.9% (range: 26.3-28.6%), respectively. In 2013, the percentages had significantly increased to 24.9 and 40.0%, respectively (P < 0.05). The median THC concentration over the 5-year period ranged from 5.2 to 6.3 ng/mL, with individual concentrations ranging up to 90 ng/mL. An average of 56% of cases were at or >5 ng/mL over the 5-year period. The prevalence of alcohol and the majority of other drugs in this same population of suspected impaired drivers submitted for testing did not change during this same 5-year period-marijuana was the only drug to show such an increase in frequency. Further, this observed increase remained after the data had been normalized to account for changes in laboratory testing procedures that occurred during this time period. Future studies need be conducted to ascertain whether the observed increase has had any effect on the incidence of crashes, serious injuries and/or traffic fatalities.
机译:2012年12月,在华盛顿州合法拥有和私人使用有限数量的大麻和大麻产品。同时,根据影响法规对州的驾驶进行了修订,以使21岁及以上年龄的驾驶员自身全血中的浓度为5 ng / mLδ(9)-四氢大麻酚(THC)。这项研究的目的是评估在可疑的驾驶案例中,大麻合法化对大麻患病率的影响。在这种情况下,将合法化前检测到的活性四氢大麻酚及其代谢产物羧基-四氢大麻酚的患病率与合法化后的患病率进行了比较。 2009-2012年,THC和羧基-THC阳性病例的年均百分比分别为19.1%(范围:18.2-20.2%)和27.9%(范围:26.3-28.6%)。 2013年,该百分比显着提高至24.9%和40.0%(P <0.05)。五年期间的四氢大麻酚中值浓度范围为5.2至6.3 ng / mL,单个浓度范围最高为90 ng / mL。在5年中,平均有56%的病例达到或超过5 ng / mL。在同一五年期间,在接受测试的同一批可疑受损驾驶员中,酒精和大多数其他药物的流行率没有变化,大麻是唯一出现频率增加的药物。此外,在将数据归一化以说明在此时间段内发生的实验室测试程序的变化之后,这种观察到的增加仍然存在。需要进行进一步的研究,以确定观察到的增加是否对撞车,严重伤害和/或交通死亡的发生率有影响。

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