Clinical trial registration and publication of randomized controlled trials.

摘要

In Reply: Dr Lash raises the issue of the independent trial assumption in determining our study power. He also requests the presentation of outcomes limited only to the person-time that had not been included in the earlier reports, to support meta-analysis. Our patient cohort did include some cases previously reported (22% of the overall cohort). However, as noted in the article, their use was based on a longer clinical follow-up and expansion of the genotyping to include multiple alleles *3, *4, *10, and *41. We agree that these cases cannot be viewed as completely independent, yet, because of the extended follow-up and new data with newly assigned CYP2D6 alleles, any distinction between previous and current person-time is not feasible.