TOTAL SYNTHESIS OF (±)-SCUTEFLORIN A

摘要

A highly efficient synthesis was developed for the first total synthesis of scuteflorin A. Scutellaria lateriflora L. (also called "American skullcap") has long been used as an herbal medicine for treating neurological disorders such as anxiety, nervous tension, and convulsions in North America and Europe.1 The therapeutic benefit of S. lateriflora has been validated by demonstrating significant anxiolytic effects of its aqueous extracts in rodent models and in healthy human volunteers. In a recent study to reveal the chemical constituents of S. lateriflora extract, two new coumarins, scuteflorin A ((+)-1) and B ((+)-2), have been isolated and the fully characterized structures are shown in Figure 1.