SYNTHESIS OF FLUORINE ANALOGS OF PROTOPORPHYRIN POTENTLALLY USEFUL FOR DIAGNOSIS AND THERAPY OF CANCER PART 3.~1 SYNTHESIS OF (2,2-DIFLUOROVINYL)-TRIFLUOROVINYL- AND (1-CHLORO-2,2-DIFLUOROVINYL)-(2,2-DIFLUOROVINYL)DEUTEROPORPHYRIN

摘要

Wittig reaction of 3-and 8-formyl deuteroporphyrin dimethyl esters (1 or 2) with triphenylphosphonium difluoromethylide,generated in situ from sodium chlordifluoroacetate an triphenylphosphine,gave 3-and 8-difluorovinyl cmpounds (3 or 4),which were iodinated to form corresponding 8-and 3-iodo compounds (5 or 6). Coupling reaction of these iodo compounds with our new bis(fluorovinyl)zinc reagents afforded the titled compounds (7 to 10)in moderate to good yields.