THREE NEW ENT-KAURANOIDS FROM ISODONPHYLLOSTACHYS

摘要

Three new ent-kzarane diterpenoids,phyllostacins C-E (1-3),together with six known analogues,oridonin (4),ponicidin (5),effusanin A (6),rabdoternin E (7),rabdoternin F (8),and macrocalyxoformin E (9),were isolated from the aerial parts of Isodon phyllostachys.The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive ID and 2D NMR analysis.All compounds were evaluated for their inhibitory activity against K562,HL60 and HepG2 (hepatoma) cell lines.