A NEW PYRROLIDINE-2,4-DIONE DERIVATIVE,VERMELHOTIN,ISOLATED FROM UNIDENTIFIED FUNGUS IFM 52672

摘要

A new pyrrolidine-2,4-dione derivative,vermelhotin (1),was isolated along with the characteristic antifungal substance,dihydroepiheveadride (2),and its analog,deoxoepiheveadride (3),from unidentified fungus IFM 52672.The structure of 1 was elucidated by the spectroscopic and X-Ray crystallographic investigation.Velmelhotin (1) was the first example of 3-acylpyrrolidine-2,4-dione (tetramic acid) derivative having further pyrane ring.