PRELIMINARY STUDY OF PALLADIUM CATALYZED IMINOANNULATION IN AN IMIDAZO[1,2-alpha]PYRIDINE SERIES

摘要

Palladium-catalyzed iminoannulation was carried out in an imidazo[l,2-a]pyridine (IP) series.tert-Butylimine of 3-haloimidazo[l,2-a]pyridine-2-carbaldehyde reacted with suitably functionalized alkynes in the presence of a catalytic amount of Pd(OAc)_2/PPh_3 and a base to yield dipyrido[l,2-a;3',4'-d]imidazoles (5).