A NEW AND CONVENIENT ACCESS TO ENANTIOPURE C_2-SYMMETRIC 2,5-DIETHYNYLPYRROLIDINE

摘要

Both(2R,5R)-and(2S,5S)-diethynylpyrrolidines were conveniently synthesized from 3,6-bis(mesyloxy)-1,7-octadiyne in optically pure forms via(R)-1-(4-methoxyphenyl)ethylamine-induced pyrrolidine ring formation,chromatographic separation of the corresponding diastereomers,and cleavage of the benzylic C-N bond.Because of its excellent acyl transfer activity,4-pyrrolidinopyridine(PPY)has been widely used as an efficient catalyst for the formation of esters and the development of its chiral derivatives is one of the current topics.