DAKIN-WEST REACTION OF N-THIOACYLPROLINES USING TRIFLUOROACETIC ANHYDRIDE: NOVEL ACCESS TO 5-TRIFLUOROMETHYLTHIAZOLES

摘要

The reaction between N-thioacylprolines and trifluoroacetic anhydride in the presence of pyridine afforded a good yield of 5-trifluoromethylthiazoles. This reaction proceeded through mesoionic l,3-thiazolium-5-olates, followed by cleavage of the pyrrolidine ring and the formation of thiazoles, introducing a trifluoromethyl group at position 5 in the thiazole ring.