SYNTHESIS OF FUNCTIONALIZED TETRAHYDRO-beta-CARBOLINE DERIVATIVES BY MODIFIED PICTET-SPENGLER REACTION

摘要

Instead of iminium salt in Pictet-Spengler reaction,a series of indole-bearing secondary enamines were synthesized through one-carbon unit transfer reactions of a tetrahydrofolate coenzyme models with tryptamine,and applied to Pictet-Spengler reaction.Reaction of the secondary enamines in acid conditions produced a series of functionalized tetrahydro-beta-carboline derivatives in good to excellent yields.