TOTAL SYNTHESIS AND ANTIOXIDATIVE ACTIVITY OF MAGNOLAMIDE FROM MAGNOLIA COCO

摘要

A simple total synthesis of naturally occurring magnolamide,N-[4-(2-formyl-5-hydroxymethylpyrrol-l-yl)butyl]-3-(4-hydroxy-3-methoxy-phenyl)-2-propenamide,from pyrrole-2,5-dicarbaldehyde was performed in six steps and its antioxidant activity was compared with probucol and resveratrol.Results showed that magnolamide markedly inhibited CuSO_4-induced oxidation of human low-density lipoprotein (IC_(50) = 9.7 muM) with similar activity to probucol and resveratrol.