Chemistry of Renieramycins. Part 2. Partial Reduction and Nucleophilic Substitution of Hexahydro-1,5-Imino-4-oxo-3-Benzazocine-7,10-Dione: Promising Method to Construct Renieramycin J from Renieramycin G Via Renieramycine E

摘要

The conversion of 1,2,3,4,5,6,7,10-octahydro-9-methoxy-3,8,11-trimethyl-1,5-imino-3-benzazocine-4,7,10-trione (8) to the corresponding alkylated compound at C-21 position (11) as an ABC ring model of renieramycin J (1j) is described. This is a promising method for converting renieramycin G (1g) into 1j via renieramycin E (1e).