CHIRAL PRIMARY AMINO AMIDE ALCOHOL ORGANOCATALYST FOR THE ASYMMETRIC MICHAEL ADDITION OF 4-HYDROXYCOUMARIN WITH alpha,beta-UNSATURATED KETONES

摘要

Chiral primary amino amide organocatalysts were designed and synthesized as new organocatalysts for the enantioselective Michael addition of 4-hydroxycoumarin with alpha,beta-unsaturated ketones to produce chiral warfarin (up to 56% ee with up to 92% yield).