A CATALYTIC C-C BOND-FORMATION WITH MINIMAL USE OF PROTECTING GROUPS: CONSTRUCTION OF FUNCTIONALIZED ISOTETRONIC ACID DERIVATIVES

摘要

A catalytic method to construct multi-functionalized isotetronic acids was developed using cyclic hemiacetals and pyruvic acid derivatives as substrates. The key to success was the combination of catalytic amounts of iron(III) trifluoroacetate and 2-mercaptopyridine. A catalytic asymmetric variant was also developed using 6,6'-dimethoxy-binaphthyl phosphate instead of 2-mercaptopyridine.