ISOQUINOLINIUM N-ARYLIMIDES AND TRANS-CYCLOOCTENES~1

摘要

The inertness of isoquinolinium N-arylimides (5a,b)versus common cycloalkenes is overcome by the highly reactive (E)-cyclooctene and (E,Z)-1,5-cyclooctadiene.NMR spectral and an X-Ray analysis established the retention of dipolarophile configuration in the cycloadducts (7a,b)and (9a,b)with were obtained in >90% yield.Acid-base catalysis effects the opening of the pyrazo-lidine ring by (#beta#)-elimination;the products are 1-[trans-2-arylaminocyclooctyl]-isoquinolines (8,10).