Synthesis Of N-A-Demethyl-20-Deethylsuaveoline,The Structure Proposed For Sellowiine

摘要

A synthesis of A-demethyl-20-deethylsuaveoline (1), the structure assigned to the Rauwolfia alkaloid sellowiine, has been accomplished for the first time through a route using intramolecular oxazole-olefin Diels-Alder reaction. The 1~H and ~13C-NMR spectral data and the specific rotation of the synthetic 1 were in disagreement with those reported for a natural sample, leaving the chemistry of this alkaloid incomplete.