Microscopic imaging is a commonly used tool in the study of microbiology. Typically, microscopic imaging is performed using a microscope equipped with digital imaging apparatuses. Traditional microscope systems can be bulky and expensive, and many efforts have been focused on developing compact, low-cost alternatives. Recently, Lee et al. reported a complementary metal oxide semiconductor (CMOS) image sensor-based self-imaging Petri dish, or "ePetri" system to allow low-cost, convenient high-resolution imaging of micro-organisms. In this study, the CMOS imaging chip serves as the substrate for cell growths. Because the pixel size of the image sensor and the size of micro-organisms are on the same order of magnitude (micrometers), typically a lens system is required to amplify the image of micro-organisms before it can be resolved by the image sensor. The authors eliminate the need for the lens system by using a subpixel motion microscopy (SPMM) technique.
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