Development of a Biodegradable Polyhydroxybutyrate-Chitosan-Rifampicin Composition for Controlled Transport of Biologically Active Compounds

摘要

The development of therapeutic systems for prolonged and targeted transport of biologically active compounds is a topical task but a challenge for practical implementation. Extensive studies of polymeric dosage forms [1] provided two basic conclusions: first, at the micro- and nanolevels, most beneficial are the biodegradable polymeric systems whose molecules are destroyed to give nontoxic intermediate or final products [2]; second, the search for polymer carriers requires the use of blend compositions provided that their physicochemical and transport characteristics are superior to these characteristics of the initial polymers [3].