The Expression Pattern of Pro- and Antiapoptotic Proteins Bax and Bcl-2 in Rat Brain Neurons in Response to Severe Hypobaric Hypoxia: The Correcting Effect of Hypoxic Preconditioning

摘要

In the early 1980s, the phenomenon of delayed neu-ronal death several days after ischemia was described in hippocampal neurons [1]. It was then demonstrated that the neuronal injury observed developed by the apop-totic mechanism (programmed cell death) with an involvement of genes and killer proteins. This neuronal death caused by severe forms of ischemia/hypoxia has been reported in susceptible brain areas other than hippocampus: neocortex, striatum, and cerebellum [2-4].