Phenothiazinium photosensitisers:V.Photobactericidal activities of chromophore-methylated phenothiazinium salts

摘要

The synthesis of chromophoric di-and trimethyl derivatives of azure A has been carried out along with the physicochemical profiling of the resulting derivatives.Structure-function relationships of the derivatives are proposed with a view to the development of novel photosensitisers with antimicrobial applications.All derivatives exhibited similar magnitudes of photosensitising efficacy in vitro to the standard dyes,azure A and toluidine blue O,but were generally more lipophilic in nature.Chromophoric methylation furnished more active photoantibacterials compared to the lead compounds,both against Gram-positive and Gram-negative organisms.