Normal range of human red blood cell acetylcholinesterase activity

摘要

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean + SD) was 0.74+0.06 delta pH units/ hour. Multivariate linear regression showed an association with age (slope +0.0008 delta pH units/hour for each year;P< 0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.