Synthesis of poly(acrylamide-co-methyl methacrylate) chemically cross-linked hydrogels and their application in controlled release of model drugs

摘要

Poly(acrylamide-co-methyl methacrylate) (poly(AAm-co-MMA)) hydrogels with chem-ical cross-links have been prepared using two monomers (acrylamide and methyl methacrylate) and cross-linker (N,N'-methylene bis acrylamide) (NN'-MBA) in different stoichiometric ratios.The ef-fects of monomer ratio and cross-linking agent concentration on the swelling behaviour of poly(AAm-co-MMA)hydrogels were investigated.Swelling parameters such as equilibrium degree of swelling and swelling ratio,and network parameters such as molecular mass between cross-links (M_c) and cross-link density (q) were determined.Depending on the monomer concentration,the M_c values of hydrogels were varied from 1452.00 to 10602.16 g/mol and q values of hydrogels were varied from 6.09 x 10~2 to 0.75 x 10~2.Depending on the cross-linking agent concentration the M_c values of hydrogels were varied from 1463.57 to 2143.94 g/mol and q values of hydrogels were varied from 5.63 x 10~2 to 3.99 x 10~2.The ability of this co-polymeric hydrogel for use in controlled release of model drugs such as benzoic acid (BA),salicylic acid (SA) and p-nitroaniline (P-NA) was also studied.