A Convenient and Efficient Synthesis of N-Acylsulfonamides in the Presence of Silica Phosphoric Acid under Heterogeneous and Solvent-Free Conditions

摘要

Reaction of sulfonamides with carboxylic acid anhydrides and chlorides in the presence of silica phosphoric acid provided N-acyl sulfonamides in good to high yields. All reactions were performed under mild conditions in solvent-free and heterogeneous systems and the products were obtained in high purity after a simple work-up. Silica phosphoric acid could be reused for 3 times without visible loss of activity.