Efficient Method for Tetrahydropyranylation of Phenols and Alcohols Using 2,4,6-Trichloro[1,3,5]triazine

摘要

Alcohols and phenols were tetrahydropyranylated in the presence of 2,4,6-trichloro[1,3,5]triazine in good to excellent yields in acetonitrile. Because of the easy preparation and good stability of tetrahydropyranyl groups in the presence of hydrides, alkylating agents, Grignard reagents, organometallic reagents, etc., they are frequently used for the protection of alcohols and phenols. In addition, they serve as stable protecting groups in peptide,.