Contribution of heterobifunctional ligands to transition metal-catalysed C-C coupling reactions

摘要

In this account the authors' latest results in C-C coupling catalysis are reviewed. First, an efficient catalytic system for the Kumada Tamao Corriu coupling reaction based on NHC-phosphine (NHC = N-heterocyclic carbene) nickel complexes is presented. Then the use of palladium complexes of chiral ferrocenyl NHC-phosphines in the asymmetric Suzuki-Miyaura coupling reaction is reported. High catalytic activities and moderate enantioselectivities (cc up to 46%) were obtained. Chiral ferrocenyl phosphine ethers were also tested in the asymmetric Suzuki-Miyaura reaction yielding good activities and moderate enantioselectivities (cc up to 37%). Finally, the original synthesis of a ferrocenyl rhodium(III) complex and its successful use as catalyst for a C-C coupling reaction via C-H activation of 2-phenylpyridine is presented.