Metformin-related colonic glucose uptake; potential role for increasing glucose disposal?-A retrospective analysis of F-18-FDG uptake in the colon on PET-CT

摘要

Aim: The use of metformin has been associated with diffusely increased colonic F-18-fluorodeoxyglucose (F-18-FDG) uptake. Interestingly, metformin use is associated with moderate weight loss. It could be hypothesized that increased colonic glucose disposal is related to this weight loss. It is unknown whether other factors influence F-18-FDG uptake in the colon. The aim of this study was to retrospectively assess independent determinants of colonic F-18-FDG uptake.