Commentary on 'Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: A meta-analysis' by Preiss et al.

摘要

High-dose statin therapy has been shown to reduce cardiovascular morbidity and mortality in high-risk patients. In general, statins are considered as having few side effects, but data from recent clinical trials suggest that these drugs may increase the incidence of diabetes. Moreover, a recent rneta-analysis of 13 randomized statin trials of over 91,000 patients with mean follow-up of 4.1 years suggested that statin therapy compared with placebo leads to a 9% increased relative risk for the development of diabetes.1 Still hitherto it is unknown whether high-dose statin therapy compared with moderate-dose statin therapy also increases the risk of diabetes. Preiss et al. performed a meta-analysis of 5 statin trials with 32,752 participants without diabetes at baseline comparing intensive-dose statin therapy with moderate-dose statin therapy.2 The following trials were included: PROVE IT-TIMI 22, A to Z, TNT, IDEAL and SEARCH.