Changes in physical activity and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort

摘要

Aims To describe change in physical activity over 1year and associations with change in cardiovascular disease risk factors in a population with screen-detected Type2 diabetes. Methods Eight hundred and sixty-seven individuals with screen-detected diabetes underwent measurement of self-reported physical activity, cardiovascular disease risk factors and modelled cardiovascular disease risk at baseline and 1year (n=736) in the ADDITION-Cambridge trial. Multiple linear regression was used to quantify the association between change in different physical activity domains and cardiovascular disease risk factors at 1year. Results There was no change in self-reported physical activity over 12months. Even relatively large changes in physical activity were associated with relatively small changes in cardiovascular disease risk factors after allowing for changes in self-reported medication and diet. For every 30 metabolic equivalent-h increase in recreational activity (equivalent to 10h/brisk walking/week), there was an average reduction of 0.1% in HbA1c in men (95%CI -0.15 to -0.01, P=0.021) and an average reduction of 2mmHg in systolic blood pressure in women (95%CI -4.0 to -0.05, P=0.045). Conclusions Few associations were observed between change in different physical activity domains and cardiovascular disease risk factors in this trial cohort. Cardiovascular disease risk reduction appeared to be driven largely by factors other than changes in self-reported physical activity in the first year following diagnosis.