Facial Flush Reaction after Alcohol Ingestion during Topical Pimecrolimus and Tacrolimus Treatment

摘要

Pimecrolimus and tacrolimus, topical calcineurin inhibitors, are approved for the treatment of atopic dermatitis and have recently been introduced for the treatment of vitiligo lesions offering the advantage to be used for a prolonged time avoiding the side effects related to the long-term use of topical steroids. Although no signs of atrophy, telangiectasia or tachyphylaxis have been described with their use, the topical treatment with tacrolimus and pimecrolimus can produce transient adverse events, generally of mild to moderate severity, such as burning, feeling of warmth, smarting, pain, soreness and rosaceiform dermatitis at the site of application [1-4].