Mono-carboxylated diaminedichloridoplatinum(iv) complexes - Selective synthesis, characterization, and cytotoxicity

摘要

(OC-6-43)-Dichlorido(N,N-dimethyl-ethane-1,2-diamine) dihydroxidoplatinum(iv) could selectively be mono-carboxylated with succinic anhydride based on the steric hindrance caused by the two methyl groups of the equatorial ligand. Subsequent esterification of the uncoordinated carboxylic acid with alcohols of different lengths (methanol, butanol, hexanol and octanol) afforded the corresponding esters. The synthesized complexes were characterized in detail by elemental analysis, ESI-MS, multinuclear (~1H, ~(13)C, ~(15)N and ~(195)Pt) NMR spectroscopy and in two cases by X-ray crystallography. Cytotoxicity of novel platinum(iv) compounds was investigated in four human cancer cell lines (CH1, A549, SW480 and SK-OV-3). Remarkably, the most lipophilic complexes showed IC_(50) values down to the low micromolar or even nanomolar range.