首页> 外文期刊>Zeitschrift fur Naturforschung, C. A Journal of Biosciences >Herbal remedies traditionally used against malaria in Ghana: Bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae)
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Herbal remedies traditionally used against malaria in Ghana: Bioassay-guided fractionation of Microglossa pyrifolia (Asteraceae)

机译:加纳传统上用于抗击疟疾的草药:小生舌草(Microglossa pyrifolia(Asteraceae)的生物测定指导分馏

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摘要

Different extracts from 11 West African plants traditionally used against malaria in Ghana were tested against both the chloroquine-sensitive strain PoW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum. Due to the promising in vitro activity of the lipophilic extract [IC50: 10.5 mug/ml (PoW); 13.1 mug/ml (Dd2)], Microglossa pyrifolia (Lam.) Kuntze (Asteraceae) was chosen for further phytochemical investigation. From active fractions 13 compounds were isolated; their structures were established on the basis of spectroscopic methods. 1-Acetyl-6E-geranylgeraniol-19-oic acid and sinapyl diangelate represent new natural compounds. The two diterpenes E-phytol [IC50: 8.5 mum (PoW); 11.5 mum (Dd2)], and 6E-geranylgeraniol-19-oic acid [IC50: 12.9 mum (PoW); 15.6 mum (Dd2)] proved to be the most active constituents in our test system. [References: 24]
机译:测试了来自传统上用于加纳疟疾的11种西非植物的不同提取物对恶性疟原虫的氯喹敏感菌株PoW和耐氯喹克隆Dd2的测试。由于亲脂性提取物具有良好的体外活性[IC50:10.5杯/毫升(PoW); 13.1杯/毫升(Dd2)],选择了Microglossa pyrifolia(Lam。)Kuntze(Asteraceae)进行进一步的植物化学研究。从活性级分中分离出13种化合物;它们的结构是在光谱方法的基础上建立的。 1-乙酰基-6E-香叶基香叶醇-19-油酸和芥子基二氯酸盐代表新的天然化合物。两个二萜E-植醇[IC50:8.5毫米(PoW); 11.5妈妈(Dd2)]和6E-香叶基香叶醇19-oic酸[IC50:12.9妈妈(PoW); 15.6妈妈(Dd2)]被证明是我们测试系统中最活跃的成分。 [参考:24]

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