Effects of vasodilators on the signal intensity of perfluorocarbon monitored by in vivo F-19-NMR spectroscopy

摘要

The effects of vasodilators on peripheral vessels were examined by monitoring the F-19-NMR signal of perfluorocarbon in vivo, Nitroglycerin, a venodilator that acts mainly on venous smooth muscle, increased the signal intensity of FC-43, whereas hydralazine, a typical arteriolar dilator that acts on arteriolar smooth muscle, decreased the signal intensity, These results indicate that the in vivo effects of vasodilators on smooth muscles of the venous and arterial systems are reflected by their effects on the signal intensity of FC-43. (C) 1997 Elsevier Science Inc.