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首页> 外文期刊>Human vaccines & immunotherapeutics. >Seroprevalence of measles, mumps and rubella among young adults, after 20 years of universal 2-dose MMR vaccination in Israel
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Seroprevalence of measles, mumps and rubella among young adults, after 20 years of universal 2-dose MMR vaccination in Israel

机译:在以色列普遍接受2剂MMR疫苗接种20年后,年轻人中的麻疹,腮腺炎和风疹的血清阳性率

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摘要

Evidence-based vaccination policy is important for the global and local efforts of achieving control over measles. In 2007, the first Israeli birth cohort to be twice vaccinated during childhood with Measles-Mumps-Rubella vaccine reached adulthood. In parallel, Israel experienced its largest measles outbreak since 1994. We aimed to assess the seroprevalence of measles IgG antibodies and concordance with rubella and mumps seroprevalence among young Israeli adults born 1988-9 in comparison to previous birth cohorts, in order to inform evidence based prevention policy. We conducted a seroprevalence study of IgG antibodies among 439Israeli adults born in 1988-9, based on a representative sample of sera collected at age 18-19 upon recruitment to mandatory military service in 2007. In total, 85.7% were seropositive for measles as compared with 95.6% in the 1996 recruitment (P < 0.001). The absolute decline was significant both for males (8.8%, P = 0.001) and females (12.1%, P < 0.001). There were no significant differences in seropositivity by gender, years of education, country of birth or smoking status. Rubella seropositivity among measles seropositives was 90.4%, significantly (P < 0.001) higher than 72.1% among measles seronegatives. Mumps seropositivity among measles seropositives was 87.0%, significantly (P < 0.001) higher than 62.3% among measles seronegatives. Results were similar for Israeli-born only. Our findings indicate that measles seroprevalence decreased after the last change in vaccination policy and reach sub-optimal level. Until global eradication is reached, a proactive vaccination program to supplement routine childhood vaccination program should be considered in Israel and in other countries.
机译:基于证据的疫苗接种政策对于全球和地方实现对麻疹的控制至关重要。 2007年,以色列第一个在儿童时期两次接种了麻疹-腮腺炎-风疹疫苗的出生队列已经成年。同时,以色列经历了自1994年以来最大的麻疹暴发。与以前的出生队列相比,我们旨在评估1988-9年出生的以色列年轻成年人中的麻疹IgG抗体的血清阳性率以及与风疹和腮腺炎的血清阳性率的一致性。预防政策。我们对1988年出生的439名以色列成年人中IgG抗体的血清阳性率进行了研究,该样本是根据2007年应征入伍后在18-19岁时收集的代表性血清样本进行的。1988年,麻疹的血清阳性率为85.7%。在1996年的招聘中占95.6%(P <0.001)。男性(8.8%,P = 0.001)和女性(12.1%,P <0.001)的绝对下降均显着。血清阳性反应在性别,受教育年限,出生国家或吸烟状况方面无显着差异。麻疹血清阳性患者中的风疹血清阳性率为90.4%,比麻疹血清阴性患者中的72.1%显着提高(P <0.001)。麻疹血清阳性患者的腮腺炎血清阳性率为87.0%,显着(P <0.001)高于麻疹血清阴性患者的62.3%。结果仅对于以色列出生的人相似。我们的研究结果表明,麻疹患者的血清阳性率在接种政策的最后一次改变后有所下降,并达到了次优水平。在达到全球根除之前,以色列和其他国家应考虑采取积极的疫苗接种计划以补充常规的儿童期疫苗接种计划。

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