Pentopyranosyl oligonucleotides systems - Communication No. 13 - The alpha-L-arabinopyranosyl-(4 ' -> 2 ')-oligonucleotide system: Synthesis and pairing properties

摘要

Among the members of a family of diastereoisomeric pentopyranosyl-(4'- 2')-oligonucleotide systems derived from D-ribose, D-xylose, L-lyxose, and L-arabinose, the a-arabinopyranosyl system shows by far the strongest Watson-Crick base pairing. The system is, in fact, one of the strongest oligonucleotide-type base-pairing systems known. It undergoes efficient cross-pairing with all the other members of the pentopyranosyl family, but not with RNA and DNA. The paper describes the synthesis and pairing of the properties of alpha-L-arabinopyranosyl-(4' --> 2')-oligonucleotides. [References: 40]