Circulating MicroRNA-122 signature in nonalcoholic fatty liver disease and cardiovascular disease: A new endocrine system in metabolic syndrome

摘要

We would like to thank Cusinato et al. for their thoughtful comments.The relative prevalence of hepatitis C virus (HCV) genotypes was 87% (genotype 1), 7% (genotype 2), 5% (genotype 3), and 1% (genotype 4).Clearly, HCV genotype is strongly associated with sustained viro-logical response (SVR) rates and with the likelihood of receiving antiviral treatment. HCV genotype was also associated witri development of cirrhosis or hepatocellular carcinoma (HCC) in our data set, but the results were not statistically significant. Specifically, for cirrhosis, the adjusted odds ratio (OR) was 0.74 (95% confidence interval [CI]: 0.52-1.06) for genotype 2 patients and 1.06 (95% CI: 0.71-1.56) for genotype 3 patients, relative to genotype 1 patients as the reference group. For HCC, the adjusted OR was 0.53 (95% CI: 0.16-1.73) for genotype 2 patients and 0.82 (95% CI: 0.25-2.7) for genotype 3 patients, relative to genotype 1 patients.