Multivariate analysis of prognostic factors in 549 patients undergoing surgical treatment of gastric cancer.

摘要

Gastric cancer is a common malignancy with high mortality rate, and surgical resection is the primary treatment.A retrospective analysis of patients who received surgical treatment for primary gastric cancer from January 2006 to December 2010 was performed. Cox univariate and multivariate analyses were performed to determine factors associated with decreased survival.A total of 549 patients were included in the analysis (421 men and 128 women) with a mean age of 59.5 years (range, 21-81 years). Radical resection was performed in 496 patients, including D1 resection in 72 cases (14.5%), D2 resection in 380 cases (76.6%), and D3 resection in 44 cases (8.9%). The follow-up ranged from 3 to 67 months, during which 368 patients were alive or censored and 181 patients died. The overall 6-month and 1-, 3-, and 5-years survival rates were 89.8%, 80.8%, 58.9%, and 49.7% respectively. Multivariate analysis indicated that tumor size > 5 cm, increasing TNM stage, no resection, receiving perioperative blood transfusion, serum albumin <37 g/L, and not receiving postoperative comprehensive treatment (Chinese medicine, chemotherapy, immunotherapy) were associated with decreased survival.Tumor size, TNM stage, extent of resection, serum albumin level, and comprehensive treatment were important prognostic factors.