Efficacy of metronidazole as second-line drug for the treatment of Helicobacter pylori infection in the Japanese population: A multicenter study in the Tokyo metropolitan area

摘要

Background With the increase in the frequency of clarithromycin-resistant Helicobacter pylori (H. pylori), there is rising concern about the decline of the eradication rate of this infection following treatment. The Tokyo Hp Study Group examined the eradication rate in response to a second-line regimen consisting of proton pump inhibitor (PPI), amoxicillin, and metronidazole by conducting a multicenter study in the Tokyo Metropolitan Area.