Electrochemical Behavior and Determination of Trifluoperazine at Decanethiol Self-Assembled Monolayer Modified Gold Electrodes

摘要

The electrochemical behavior of trifluoperazine at decanethiol self-assembled monolayer (SAM) modified gold electrodes (i. e. C_(10) H_(21) SH/Au) has been studied, Trifluoperazine can effectively accumulate on C_(10) H_(21) SH/Au electrodes and generate a sensitive anodic peak at about 0.63 V (vs. SCE) in 0.05 mol/L pH 9.4 Na_2 B_4 O_7 buffer solution. Under the selected conditions, the anodic peak current was linear to trifluoperazine concentration in the range of 5.0 X 10~(-7)-3.O X 10~(-3) mol/Lwith correlation coefficient of 0.997, the detection limit was 3.0 X 10~(-5) mol/L. This method was applied to the determination of trifluoperazine in drug samples and the recovery was 97.3%-104.0% It was found that sodium dodecyl sulfate (SDS) could make the anodic peak current increase. In the presence of SDS, the peak at about 0.63 V turned into two peaks, resulting from the change of the electrochemical mechanism.