Statin toxicity from macrolide antibiotic coprescription: A population based cohort study: Patel A, Shariff S, Bailey D, et al. Ann Intern Med 2013;158:869-76.

摘要

Clarithromycin and erythromycin both inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), whereas azithromycin does not. Statins, such as atorvastatin, lovastatin, and simvastatin, are metabolized by CYP34A. Inhibition of CYP34A can cause accumulation of these statins and increase the incidence of their toxic effects. This retrospective cohort study compared the rates of statin toxicity among users of clarithromycin and erythromycin to users of azithromycin in Canada.