INTUSSUSCEPTION AFTER ROTAVIRUS VAC- CINES REPORTED TO UNITED STATES VACCINE ADVERSE EVENT REPORTING SYSTEM, 2006-2012. Haber P, Patel M, Pan Y, et al. Pediatrics 2013;131:1042-9.

摘要

The rotaviras vaccine has been shown to decrease treatment costs and hospitalization rates for pediatric gastroenteritis. Two live, oral rotavirus vaccines, RV5 and RV1, are currently used in the United States. Previous international studies of RV5 and RV1 have shown an excess risk of 1-2 cases of intussusception per 100,000 vaccinated infants. A prior study using the Vaccine Adverse Event Reporting System (VAERS) suggested that intussusception frequently occurred 3-6 days after initial vaccination with RV5, however, due to small sample size, conclusions could not be made.This study utilized a self-controlled risk interval analysis to evaluate the temporal relationship between intussusception and the RV5 rotavirus vaccine based on reports to VAERS from 2006-2012. It also provided the first descriptive data of intussusception reports from the RV1 vaccine.